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KMID : 0352519850220030259
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Korea Univercity Medical Journal
1985 Volume.22 No. 3 p.259 ~ p.267
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Teratogenicity of Triamcinolone Acetonide on Palatogenesis in Ddy Mice
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李柱元/Lee, Joo-Won
崔平華/全容赫/Choe, Pyung-Hwa/Chun, Yong-Hyuck
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Abstract
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Glucocorticoids in conjuction with other hormones or growth factors are known to be essential for the normal development of the secondary palate, a series of closely timed and finely tuned processes, and while on the other hand, it is well established that these steroids, when administered in therapeutic doses to several experimental animals, inhibit closure of the fetal seco_ldars- palate. But various strains of inbred mice exhibit different degrees of susceptibility to glucocorticoid-induced cleft palate and the mechanisms by which it causes this effect remain controversial.
Therefore, teratogenic effect of triamcinolone acetonide on DDY mouse fetuses in vivo, following intramuscular injection twice for each on days between 12.5-15.5 of gestation with successive 12 hour interval, v; ere analysed especially on stage response or sensitive period for TAC-in duccd cleft palate and correlation, between fetal growth retardation, maternal weight los and incidence of cleft palate and observed abnormal process of palatal development proceeding cleft palate histologically.
The results obtained are as follows:
1. The most sensitive stage to cleft palate induction in DDY mice following TAC treatment v,,as early stage of gala.togenesis but during the period, early development of the palatal shelves in treated fetu. es proceeded normally and palatogenesis was resistant to the effects of T111C before 13 a -d after 14.5 day of gestation.
2. The frequency of cleft palate induction was increased in proportion to the degree of
decreased maternal and fetal weight gain following TAC treatment which suggest that
there was a close correlation between fetal growth retardation and maternal weight loss
and induction of cleft palate.
3. No difference was seen histologically between control and treated in the changes of the
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